SURVIVAL ANALYSIS OF PEDIATRIC WILMS TUMORBASED ON RISK STRATIFICATION

Jurnal Urologi Indonesia

Andy¹  Yacobda HamonanganSigumonrong² 

[1] Department of Urology, Faculty of Medicine/Universitas Indonesia, H. Adam Malik Hospital, Medan;Department of Urology, Faculty of Medicine/Universitas Sumatera Utara, H. Adam Malik Hospital, Medan;

关键词: Wilms tumor;    prognostic factors;    Indonesia;    survival;    mortality;   

DOI  :  10.32421/juri.v29i1.712

来源: DOAJ

【 摘 要 】

Objective: This study aims to determine prognostic factors of WT patient in Adam Malik Hospital, Medan. Material & Methods:at Adam Malik Hospital, Medan. Univariate and multivariate Cox regression analyses were performed to determine independent prognostic factors for WT. The primary endpoint of this study were patients’ overall survival (OS) obtained by performing Kaplan-Meier analysis on significant variables. Results: From the univariate Cox regression analysis, gender was found to be the sole significant factor (HR = 0.218, p = 0.005) with males have a higher hazard ratio. The multivariate Cox regression analysis yielded age of diagnosis (HR = 13.860, p = 0.014) and incomplete tumor removals (HR = 0.056, p = 0.008). Kaplan-Meier analysis were performed on three significant variables mentioned before. Only gender yielded a significant Mantel-Cox log-rank score (p = 0.002) with male patients were found to have better survivability (which median survival 476 days compared to females’ 11 days). The survival of the boys was 45.45% while all of the girls did not survive until the cut-off. Conclusion: Three prognostic factors, including children’s gender, age of diagnosis, and tumor removal status, were confirmed to be prognostic factors for the overall survival of children with WT. Further studies covering broader demographic areas were suggested to confirm significant results.

【 授权许可】

Unknown