Lipidomic Biomarkers in Polycystic Ovary Syndrome and Endometrial Cancer

International Journal of Molecular Sciences

Jafaru Abu¹  MohamadNasir Shafiee²  CatharineA. Ortori³  DavidA. Barrett³  William Atiomo⁴  NigelP. Mongan⁵ 

[1] Department of Obstetrics and Gynaecology, City Hospital, Nottingham University Hospital, Nottingham NG5 1PB, UK;Department of Obstetrics and Gynaecology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia;Division of Advanced Materials and Healthcare Technologies School of Pharmacy, Centre for Analytical Bioscience, University of Nottingham, University Park, Nottingham NG7 2RD, UK;Division of Obstetrics and Gynaecology and Child Health, School of Medicine, Faculty of Medicine and Health Sciences, University of Nottingham, Queen’s Medical Centre, Nottingham University Hospital, Derby Road, Nottingham NG7 2UH, UK;University of Nottingham Biodiscovery Institute, University of Nottingham LE12 5RD, UK;

关键词: endometrial cancer;    lipidomic;    biomarkers;    PCOS;   

DOI  :  10.3390/ijms21134753

来源: DOAJ

【 摘 要 】

Women with polycystic ovary syndrome (PCOS) are more likely to develop endometrial cancer (EC). The molecular mechanisms which increase the risk of EC in PCOS are unclear. Derangements in lipid metabolism are associated with EC, but there have been no studies, investigating if this might increase the risk of EC in PCOS. This was a cross-sectional study of 102 women in three groups of 34 (PCOS, EC and controls) at Nottingham University Hospital, UK. All participants had clinical assessments, followed by obtaining plasma and endometrial tissue samples. Lipidomic analyses were performed using liquid chromatography (LC) coupled with high resolution mass spectrometry (HRMS) and the obtained lipid datasets were screened using standard software and databases. Using multivariate data analysis, there were no common markers found for EC and PCOS. However, on univariate analyses, both PCOS and EC endometrial tissue samples showed a significant decrease in monoacylglycerol 24:0 and capric acid compared to controls. Further studies are required to validate these findings and investigate the potential role of monoacylglycerol 24:0 and capric acid in the link between PCOS with EC.

【 授权许可】

Unknown