The Oral Administration of Sanguisorba officinalis Extract Improves Physical Performance through LDHA Modulation

Molecules

Syng-Ook Lee¹  JungHo Han²  Ki-Tae Ha²  Hee-Jin Choi²  MinJeong Kim³  Dongryeol Ryu³  Sung-Jin Bae⁴  JungSook Jin⁴ 

[1] Department of Food Science and Technology, Keimyung University, Daegu 42601, Gyeongsang, Korea;Department of Korean Medical Science, School of Korean Medicine, Pusan National University, Yangsan 50612, Gyeongnam, Korea;Department of Molecular Cell Biology, Biomedical Institute for Convergence at SKKU (BICS), School of Medicine, Sungkyunkwan University (SKKU), Suwon 16419, Gyeonggi-do, Korea;Healthy Aging Korean Medical Research Center, Pusan National University, Yangsan 50612, Gyeongnam, Korea;

关键词: Sanguisorba officinalis L.;    herbal medicine;    physical performance;    LDHA;    glycolysis;   

DOI  :  10.3390/molecules26061579

来源: DOAJ

【 摘 要 】

Muscle fatigue is induced by an acute or chronic physical performance inability after excessive physical activity often associated with lactate accumulation, the end-product of glycolysis. In this study, the water-extracted roots of Sanguisorba officinalis L., a herbal medicine traditionally used for inflammation and diarrhea, reduced the activities of lactate dehydrogenase A (LDHA) in in vitro enzyme assay myoblast C2C12 cells and murine muscle tissue. Physical performance measured by a treadmill test was improved in the S. officinalis-administrated group. The analysis of mouse serum and tissues showed significant changes in lactate levels. Among the proteins related to energy metabolism-related physical performance, phosphorylated-AMP-activated protein kinase alpha (AMPKα) and peroxisome proliferator-activated receptor-coactivator-1 alpha (PGC-1α) levels were enhanced, whereas the amount of LDHA was suppressed. Therefore, S. officinalis might be a candidate for improving physical performance via inhibiting LDHA and glycolysis.

【 授权许可】

Unknown