Prognostic significance of tumor-infiltrating lymphocytes in patients with operable tongue cancer

Radiation Oncology

Ann-Lii Cheng¹  Bing-Shen Huang²  Chun-Wei Wang³  Hsiang-Kuang Liang³  Keng-Hsueh Lan³  Wan-Yu Chen³  Sung-Hsin Kuo³  Yih-Leong Chang⁴  Chen-Tu Wu⁴ 

[1] Cancer Research Center, National Taiwan University College of Medicine;Department of Radiation Oncology, Chang Gung Memorial Hospital and Chang Gung University;Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital;Graduate Institute of Pathology, College of Medicine, National Taiwan University;

关键词: Tongue cancer;    Head neck cancer;    Adjuvant;    Tumor-infiltrating lymphocytes;    Prognosis;   

DOI  :  10.1186/s13014-018-1099-6

来源: DOAJ

【 摘 要 】

Abstract Background Our aim was to investigate the prognostic significance of tumor-infiltrating lymphocytes (TILs) in operable tongue cancer patients. Methods The presence of CD3+, CD4+, CD8+, and forkhead box protein P3-positive (FOXP3+) TILs in tumor tissues obtained from 93 patients during surgery was examined using immunohistochemistry. Results The 3-year overall survival (OS) of patients with a low CD8/FOXP3 ratio was significantly lower than that of patients with a high CD8/FOXP3 ratio (63.8% vs. 87.3%, p = 0.001). Patients with high FOXP3 had a significantly lower 3-year regional recurrence-free survival (RRFS) than did patients with low FOXP3 (49.3% vs. 87.3%, univariate log rank p = 0.000). A low CD4/FOXP3 ratio (68.4% vs. 93.7%, univariate log rank p = 0.002) was significantly unfavorable prognostic factors for 3-year distant metastasis-free survival (DMFS). Conclusions In addition to clinicopathological characteristics, TIL markers represent prognosticators for clinical outcomes.

【 授权许可】

Unknown