Stability of freeze-dried pH-responsive dextrin nanogels containing doxorubicin

Asian Journal of Pharmaceutical Sciences

Pornsak Sriamornsak¹  Somkamol Manchun¹  Crispin R. Dass² 

[1] Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand;School of Pharmacy, Faculty of Health Sciences, Curtin University, Perth 6845, Australia;

关键词: Stability;    Nanogels;    Dextrin;   

DOI  :  10.1016/j.ajps.2015.09.006

来源: DOAJ

【 摘 要 】

Induction of non-specific toxicities by doxorubicin (DOX) has restricted conventional DOX-based chemotherapy. pH-responsive dextrin nanogels (DNGs) have been fabricated in order to incorporate and deliver DOX to specific (targeted) sites. However, adequate stability studies of DOX-loaded DNGs are required for selection of storage conditions. The aim of this study was therefore to evaluate the accelerated (25 °C/60% RH) and long-term (5 °C) stability of DNGs prepared with formaldehyde (FDNGs) and glyoxal (GDNGs) as cross-linker by determining the change in their physicochemical properties. The mean diameter decreased with time during long-term storage. The drug content between freshly prepared (initial day) and after storage at 5 °C for 180 days of DOX-loaded FDNGs and DOX-loaded GDNGs was not significantly different (p > 0.05), but decreased after storage under the accelerated condition. The release of DOX from all DNGs was pH-dependent. However, DNGs kept under the accelerated condition showed higher amount of DOX release than those stored at 5 °C and the freshly prepared ones. The results indicate that the stability of DNGs could be improved by their storage at 5 °C.

【 授权许可】

Unknown