Targeting Myeloid-Derived Suppressor Cells in Ovarian Cancer

Cells

Naoko Komura¹  Seiji Mabuchi²  Tomoyuki Sasano³ 

[1] Department of Obstetrics and Gynecology, Kaizuka City Hospital, Osaka 597-0015, Japan;Department of Obstetrics and Gynecology, Nara Medical University, Nara 634-8522, Japan;Department of Obstetrics and Gynecology, Osaka Saiseikai Nakatsu Hospital, Osaka 530-0012, Japan;

关键词: MDSC;    ovarian cancer;    survival;    therapeutic target;    tumor microenvironment;   

DOI  :  10.3390/cells10020329

来源: DOAJ

【 摘 要 】

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that exhibit immunosuppressive activity. They also directly stimulate tumor cell proliferation, metastasis, and angiogenesis. In ovarian cancer, there are increased numbers of circulating or tumor-infiltrating MDSCs, and increased frequencies of MDSCs are associated with a poor prognosis or an advanced clinical stage. Moreover, in murine models of ovarian cancer, MDSC depletion has shown significant growth-inhibitory effects and enhanced the therapeutic efficacy of existing anticancer therapies. In this review, we summarize the current knowledge on MDSC biology, clinical significance of MDSC, and potential MDSC-targeting strategies in ovarian cancer.

【 授权许可】

Unknown