The Predictive Role of the Biomarker Kidney Molecule-1 (KIM-1) in Acute Kidney Injury (AKI) Cisplatin-Induced Nephrotoxicity

International Journal of Molecular Sciences

Smaranda Radu¹  EvelinaMaria Gosav²  Mariana Floria²  Ciprian Rezus²  DanielaMaria Tanase²  Alexandru Carauleanu³  ClaudiaFlorida Costea⁴  Manuela Ciocoiu⁵  MinelaAida Maranduca⁶  CristinaMihaela Lacatusu⁷ 

[1] Department of Cardiology, “Grigore T. Popa” University of Medicine and Pharmacy, 700111 Iasi, Romania;Department of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700111 Iasi, Romania;Department of Obstetrics and Gynecology, “Grigore T. Popa” University of Medicine and Pharmacy, 700111 Iasi, Romania;Department of Ophthalmology, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania;Department of Pathophysiology, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania;Internal Medicine Clinic, “Sf. Spiridon” County Clinical Emergency Hospital Iasi, 700115 Iasi, Romania;Unit of Diabetes, Nutrition and Metabolic Diseases, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania;

关键词: kidney injury molecule-1;    acute kidney injury;    cisplatin nephrotoxicity;   

DOI  :  10.3390/ijms20205238

来源: DOAJ

【 摘 要 】

Acute kidney injury (AKI) following platinum-based chemotherapeutics is a frequently reported serious side-effect. However, there are no approved biomarkers that can properly identify proximal tubular injury while routine assessments such as serum creatinine lack sensitivity. Kidney-injury-molecule 1 (KIM-1) is showing promise in identifying cisplatin-induced renal injury both in vitro and in vivo studies. In this review, we focus on describing the mechanisms of renal tubular cells cisplatin-induced apoptosis, the associated inflammatory response and oxidative stress and the role of KIM-1 as a possible biomarker used to predict cisplatin associated AKI.

【 授权许可】

Unknown