Galectins as Molecular Targets for Therapeutic Intervention

International Journal of Molecular Sciences

Kevin H. Mayo¹  Michelle C. Miller¹  Ruud P. M. Dings²  Robert J. Griffin² 

[1] Department of Biochemistry, Molecular Biology & Biophysics, University of Minnesota, Minneapolis, MN 55455, USA;Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA;

关键词: galectins;    carbohydrates;    apoptosis;    cell adhesion;    protein structure;    cancer;    galectin-targeted therapeutics;   

DOI  :  10.3390/ijms19030905

来源: DOAJ

【 摘 要 】

Galectins are a family of small, highly conserved, molecular effectors that mediate various biological processes, including chemotaxis and angiogenesis, and that function by interacting with various cell surface glycoconjugates, usually targeting β-galactoside epitopes. Because of their significant involvement in various biological functions and pathologies, galectins have become a focus of therapeutic discovery for clinical intervention against cancer, among other pathological disorders. In this review, we focus on understanding galectin structure-function relationships, their mechanisms of action on the molecular level, and targeting them for therapeutic intervention against cancer.

【 授权许可】

Unknown