Cutaneous and Vascular Deposits of 18F-NaF by PET/CT in the Follow-Up of Patients with Pseudoxanthoma Elasticum

Journal of Clinical Medicine

Juan Luis Carrillo-Linares¹  Miguel Ángel Sánchez-Chaparro¹  Pedro Valdivielso¹  María García-Fernández¹  Belén Murcia-Casas²  Eugenia Lillo³  Reinaldo Chicharo de Freitas³  Francisco Garcia-Argüello³  Antonio Gutierrez-Cardo⁴  Isabel Baquero-Aranda⁵ 

[1] Biomedical Research Institute of Malaga (IBIMA), 29010 Malaga, Spain;Internal Medicine Unit, Virgen de la Victoria Hospital, 29010 Malaga, Spain;Molecular Imaging Unit, Centro de Investigaciones Médico Sanitarias (CIMES), Fundación General de la Universidad de Málaga, 29010 Málaga, Spain;Nuclear Medicine Department, Regional Hospital, 29010 Malaga, Spain;Ophtalmology Unit, Virgen de la Victoria Hospital, 29010 Malaga, Spain;

关键词: pseudoxanthoma elasticum;    inorganic pyrophosphate;    microcalcification;    18F-NaF;    PET/CT;   

DOI  :  10.3390/jcm10122588

来源: DOAJ

【 摘 要 】

Active microcalcification of elastic fibers is a hallmark of pseudoxanthoma elasticum and it can be measured with the assessment of deposition of 18F-NaF using a PET/CT scan at the skin and vascular levels. It is not known whether this deposition changes over time in absence of specific therapy. We repeated in two years a PET/CT scan using 18F-NaF as a radiopharmaceutical in patients with the disease and compared the deposition at skin and vessel. Furthermore, calcium score values at the vessel wall were also assessed. Main results indicate in the vessel walls that calcification progressed in each patient; by contrast, the active microcalcification, measured and target-to-background ratio showed reduced active deposition. By contrast, at skin levels (neck and axillae) the uptake of the pharmaceutical remains unchanged. In conclusion, because calcification in the arterial wall is not specific for pseudoxanthoma elasticum condition, the measurement of the deposition of 18F-NaF in the neck might be potentially used as a surrogate marker in future trials for the disease.

【 授权许可】

Unknown