Potential Role of microRNAs in inducing Drug Resistance in Patients with Multiple Myeloma

Cells

Roberta Ettari¹  Alessandra Bitto²  Alessandro Allegra³  Vanessa Innao³ 

[1] Department of Chemical, Biological, Pharmaceutical and Environmental Chemistry, University of Messina, 98100 Messina, Italy;Department of Clinical and Experimental Medicine, University of Messina, 98125 Messina, Italy;Department of Human Pathology in Adulthood and Childhood, University of Messina, 98125 Messina, Italy;

关键词: micro-RNA;    multiple myeloma;    chemoresistance;    bone marrow microenvironment;    antagomir;    miRNA mimics;   

DOI  :  10.3390/cells10020448

来源: DOAJ

【 摘 要 】

The prognosis for newly diagnosed subjects with multiple myeloma (MM) has significantly progressed in recent years. However, most MM patients relapse and after several salvage therapies, the onset of multidrug resistance provokes the occurrence of a refractory disease. A continuous and bidirectional exchange of information takes place between the cells of the microenvironment and neoplastic cells to solicit the demands of cancer cells. Among the molecules serving as messengers, there are microRNAs (miRNA), a family of small noncoding RNAs that regulate gene expression. Numerous miRNAs are associated with drug resistance, also in MM, and the modulation of their expression or activity might be explored to reverse it. In this review we report the most recent studies concerning the relationship between miRNAs and chemoresistance to the most frequently used drugs, such as proteasome inhibitors, steroids, alkylating agents and immunomodulators. The experimental use of antagomirs or miRNA mimics have successfully been proven to counteract chemoresistance and display synergistic effects with antimyeloma drugs which could represent a fundamental moment to overcome resistance in MM treatment.

【 授权许可】

Unknown