Two cases of intracranial gliomatosis in different types: clinical manifestations and radiological features

Chinese Journal of Contemporary Neurology and Neurosurgery

Yin-hong LIU¹  Jing HE¹  Ping GAO¹  Yun JIANG¹  Cheng SHA²  Juan CHEN³ 

[1] Department of Neurology,Beijing Hospital, Beijing 100730, China;Department of Neurosurgery,Beijing Hospital, Beijing 100730, China;Department of Radiology, Beijing Hospital, Beijing 100730, China;

关键词: Glioma;    Brain neoplasms;    Meningeal neoplasms;    Magnetic resonance imaging;    Immunohistochemistry;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objective To report one case of gliomatosis cerebri (GC)and one case of leptomeningeal gliomatosis (LG), both of them were clearlydiagnosed by brain biopsy. Methods and Results 1) The GCpatient was a 48-year-old male who presented with epilepsy and focalneurological deficits. Cranial MRI revealed diffuse white matter lesions inbilateral cerebral hemispheres without obvious mass effect and enhancement.Immunohistochemical staining revealed that tumor cells and proliferative glialcells were positive for glial fibrillary acidic protein (GFAP). Ki-67 labelingindex was about 10% . 2) The LG patient was a 30-year-old female who mainlypresented with high intracranial pressure and epilepsy. Repeated cranial MRIrevealed aggressive enlargement of subarachnoid space and ventricles, multipleencapsulated cysts in sulci and fissures, and parenchymal infiltration. Strongenhancement in meninges and the encapsulated cysts could be seen incontrast-enhanced images. Histologically, dense and uneven distribution of tumorcells was the main feature. Obvious atypia of nuclei and proliferation of smallvessels could be seen. Tumor cells were positive for GFAP. Ki-67 labeling indexwas about 5% . By brain biopsy, both cases were diagnosed as anaplasticastrocytoma (WHO Ⅲ). The principle of treatment was temozolomidechemotherapy. Conclusions For intracranial gliomatosis,relatively distinct characteristics in brain MRI could indicate the diagnosis.Brain biopsy should be done early as possible for a clear diagnosis.

 

	DOI: 10.3969/j.issn.1672-6731.2015.12.013

 

【 授权许可】

Unknown