Ascites Volumes and the Ovarian Cancer Microenvironment

Frontiers in Oncology

TC Wu¹  Chien-Fu Hung¹  Zaver M. Bhujwalla²  Yelena Mironchik³  Balaji Krishnamachary³  Flonné B. Wildes³  Marie-France Penet⁴ 

[1] Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States;Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, United States;Division of Cancer Imaging Research, The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States;Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States;

关键词: ovarian cancer;    ascites;    MRI;    vascular volume and permeability;    total choline;   

DOI  :  10.3389/fonc.2018.00595

来源: DOAJ

【 摘 要 】

Epithelial ovarian cancer is the leading cause of death from gynecologic malignancy among women in developed countries. Epithelial ovarian cancer has a poor prognosis, due to the aggressive characteristics of the disease combined with the lack of effective therapies. Options for late-stage ovarian cancer are limited and invasive, especially once malignant ascites develops. Malignant ascites, a complication observed in terminal ovarian cancer, significantly contributes to poor quality of life and to mortality. Excess accumulation of fluid in the peritoneal cavity occurs due to a combination of impaired fluid drainage and increased net filtration, mostly due to increasing intraperitoneal vascular permeability. Here we applied non-invasive magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI) of syngeneic mouse tumors in vivo, and high-resolution 1H MRS of mouse tumor extracts, to characterize the relationship between ascites volumes and the vasculature and metabolism of an experimental model of ovarian cancer. Differences were observed in the tumor vasculature and metabolism in tumors based on ascites volumes that provide new insights into the development of this condition.

【 授权许可】

Unknown