The oral microbiome in alcohol use disorder: a longitudinal analysis during inpatient treatment

Journal of Oral Microbiology

AT Brooks¹  D Goldman²  N Kazmi³  NJ Ames³  RT Tuason³  BK Meeks³  GR Wallen³  JJ Barb³  M Krumlauf³  KA Maki³ 

[1] Center for Scientific Review, National Institutes of Health;Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health;National Institutes of Health, Clinical Center;

关键词: oral microbiome;    alcohol use disorder;    ion torrent;    16s rrna;    boas;    periodontal disease;    hmp;   

DOI  :  10.1080/20002297.2021.2004790

来源: DOAJ

【 摘 要 】

Background Alcohol use disorder (AUD)-induced disruption of oral microbiota can lead to poor oral health; there have been no studies published examining the longitudinal effects of alcohol use cessation on the oral microbiome. Aim To investigate the oral microbiome during alcohol cessation during inpatient treatment for AUD. Methods Up to 10 oral tongue brushings were collected from 22 AUD patients during inpatient treatment at the National Institutes of Health. Alcohol use history, smoking, and periodontal disease status were measured. Oral microbiome samples were sequenced using 16S rRNA gene sequencing. Results Alpha diversity decreased linearly during treatment across the entire cohort (P = 0.002). Alcohol preference was associated with changes in both alpha and beta diversity measures. Characteristic tongue dorsum genera from the Human Microbiome Project such as Streptococcus, Prevotella, Veillonella and Haemophilus were highly correlated in AUD. Oral health-associated genera that changed longitudinally during abstinence included Actinomyces, Capnocytophaga, Fusobacterium, Neisseria and Prevotella. Conclusion The oral microbiome in AUD is affected by alcohol preference. Patients with AUD often have poor oral health but abstinence and attention to oral care improve dysbiosis, decreasing microbiome diversity and periodontal disease-associated genera while improving acute oral health.

【 授权许可】

Unknown