Intestinal Dysbiosis and Biotin Deprivation Induce Alopecia through Overgrowth of Lactobacillus murinus in Mice

Cell Reports

Masayuki Amagai¹  Manabu Ohyama¹  Wataru Suda²  Toshiaki Teratani³  Toshiro Sato³  Makoto Naganuma³  Kentaro Miyamoto³  Shinta Mizuno³  Yohei Mikami³  Takanori Kanai³  Atsushi Hayashi³  Ryo Aoki³  Nobuhiko Kamada⁴  Masahira Hattori⁵  Shinji Fukuda⁶ 

[1] Department of Dermatology, Keio University School of Medicine, Tokyo 160-8582, Japan;Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160-8582, Japan;Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan;Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA;Graduate School of Frontier Sciences, University of Tokyo, Chiba 227-8561, Japan;Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0052, Japan;

关键词: Lactobacillus murinus;    alopecia;    gut microbiota;    biotin-deficiency;    dysbiosis;    microbiome;    metabolome;   

DOI  :  10.1016/j.celrep.2017.07.057

来源: DOAJ

【 摘 要 】

Metabolism by the gut microbiota affects host physiology beyond the gastrointestinal tract. Here, we find that antibiotic-induced dysbiosis, in particular, overgrowth of Lactobacillus murinus (L. murinus), impaired gut metabolic function and led to the development of alopecia. While deprivation of dietary biotin per se did not affect skin physiology, its simultaneous treatment with vancomycin resulted in hair loss in specific pathogen-free (SPF) mice. Vancomycin treatment induced the accumulation of L. murinus in the gut, which consumes residual biotin and depletes available biotin in the gut. Consistently, L. murinus induced alopecia when monocolonized in germ-free mice fed a biotin-deficient diet. Supplementation of biotin can reverse established alopecia symptoms in the SPF condition, indicating that L. murinus plays a central role in the induction of hair loss via a biotin-dependent manner. Collectively, our results indicate that luminal metabolic alterations associated with gut dysbiosis and dietary modifications can compromise skin physiology.

【 授权许可】

Unknown