Drug Delivery Nanosystems for the Localized Treatment of Glioblastoma Multiforme

Materials

D. Serrano¹  C. de la Torre²  R. Martínez-Máñez²  L. Nam³  C. Coll³  E. Ruiz-Hernández³  L.C. S. Erthal³  M.J. Santos-Martínez⁴ 

[1] Departamento de Farmacia Galenica y Tecnologia Alimentaria, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain;Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, 46010 València, Spain;School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin (TCD), Dublin 2, Ireland;Trinity Biomedical Sciences Institute, TCD, Dublin 2, Ireland;

关键词: drug delivery;    glioblastoma multiforme;    chemotherapy;    local treatment;    nanoparticles;    theranostics;    contrast agents;    gene delivery;    mesoporous silica nanoparticles;   

DOI  :  10.3390/ma11050779

来源: DOAJ

【 摘 要 】

Glioblastoma multiforme is one of the most prevalent and malignant forms of central nervous system tumors. The treatment of glioblastoma remains a great challenge due to its location in the intracranial space and the presence of the blood–brain tumor barrier. There is an urgent need to develop novel therapy approaches for this tumor, to improve the clinical outcomes, and to reduce the rate of recurrence and adverse effects associated with present options. The formulation of therapeutic agents in nanostructures is one of the most promising approaches to treat glioblastoma due to the increased availability at the target site, and the possibility to co-deliver a range of drugs and diagnostic agents. Moreover, the local administration of nanostructures presents significant additional advantages, since it overcomes blood–brain barrier penetration issues to reach higher concentrations of therapeutic agents in the tumor area with minimal side effects. In this paper, we aim to review the attempts to develop nanostructures as local drug delivery systems able to deliver multiple agents for both therapeutic and diagnostic functions for the management of glioblastoma.

【 授权许可】

Unknown