期刊论文详细信息
Nanomaterials
Lipid-Based Nanovesicular Drug Delivery Systems
Francesca Susa1  Tania Limongi1  Enzo di Fabrizio1  Bruno Torre1  Marco Allione1  Roberto Pisano1  Monica Marini1 
[1] Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy;
关键词: lipid vesicles;    niosomes;    proniosomes;    ethosomes;    transferosomes;    pharmacosomes;   
DOI  :  10.3390/nano11123391
来源: DOAJ
【 摘 要 】

In designing a new drug, considering the preferred route of administration, various requirements must be fulfilled. Active molecules pharmacokinetics should be reliable with a valuable drug profile as well as well-tolerated. Over the past 20 years, nanotechnologies have provided alternative and complementary solutions to those of an exclusively pharmaceutical chemical nature since scientists and clinicians invested in the optimization of materials and methods capable of regulating effective drug delivery at the nanometer scale. Among the many drug delivery carriers, lipid nano vesicular ones successfully support clinical candidates approaching such problems as insolubility, biodegradation, and difficulty in overcoming the skin and biological barriers such as the blood–brain one. In this review, the authors discussed the structure, the biochemical composition, and the drug delivery applications of lipid nanovesicular carriers, namely, niosomes, proniosomes, ethosomes, transferosomes, pharmacosomes, ufasomes, phytosomes, catanionic vesicles, and extracellular vesicles.

【 授权许可】

Unknown   

  文献评价指标  
  下载次数:0次 浏览次数:0次