Lipid-Based Nanovesicular Drug Delivery Systems

Nanomaterials

Francesca Susa¹  Tania Limongi¹  Enzo di Fabrizio¹  Bruno Torre¹  Marco Allione¹  Roberto Pisano¹  Monica Marini¹ 

[1] Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Turin, Italy;

关键词: lipid vesicles;    niosomes;    proniosomes;    ethosomes;    transferosomes;    pharmacosomes;   

DOI  :  10.3390/nano11123391

来源: DOAJ

【 摘 要 】

In designing a new drug, considering the preferred route of administration, various requirements must be fulfilled. Active molecules pharmacokinetics should be reliable with a valuable drug profile as well as well-tolerated. Over the past 20 years, nanotechnologies have provided alternative and complementary solutions to those of an exclusively pharmaceutical chemical nature since scientists and clinicians invested in the optimization of materials and methods capable of regulating effective drug delivery at the nanometer scale. Among the many drug delivery carriers, lipid nano vesicular ones successfully support clinical candidates approaching such problems as insolubility, biodegradation, and difficulty in overcoming the skin and biological barriers such as the blood–brain one. In this review, the authors discussed the structure, the biochemical composition, and the drug delivery applications of lipid nanovesicular carriers, namely, niosomes, proniosomes, ethosomes, transferosomes, pharmacosomes, ufasomes, phytosomes, catanionic vesicles, and extracellular vesicles.

【 授权许可】

Unknown