MCP‐1 and eotaxin‐1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Jonathan Elofson¹  Laura Jastrzab¹  Zachary A. Miller¹  Gil D. Rabinovici¹  Laura Mitic¹  Ryan Fitch¹  Bruce L. Miller¹  Aimee W. Kao¹  Matthew J. Wynn¹  Joel H. Kramer¹  Matthew A. Lalli²  Kenneth S. Kosik²  Brianne M. Bettcher³ 

[1] Memory and Aging CenterDepartment of NeurologyUniversity of CaliforniaSan FranciscoSan FranciscoCAUSA;Neuroscience Research InstituteDepartment of Molecular, Cellular, and Developmental BiologyUniversity of CaliforniaSanta BarbaraSanta BarbaraCAUSA;Rocky Mountain Alzheimer's Disease CenterDepartments of Neurosurgery and NeurologyUniversity of Colorado Anschutz School of MedicineAuroraCAUSA;

关键词: Inflammation;    Neuropsychology;    Chemokines;    Neuroimaging;    Episodic memory;   

DOI  :  10.1016/j.dadm.2016.05.004

来源: DOAJ

【 摘 要 】

Abstract Introduction MCP‐1 and eotaxin‐1 are encoded on chromosome 17 and have been shown to reduce hippocampal neurogenesis in mice. We investigated whether these chemokines selectively associate with memory in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia. Methods MCP‐1 and eotaxin‐1 were assayed in controls, MCI, and AD dementia patients with varying phenotypes (n = 171). A subset of 55 individuals had magnetic resonance imaging (MRI) scans available. Composite scores for cognitive variables were created, and medial temporal lobe volumes were obtained. Results An interaction was noted between MCP‐1 and eotaxin‐1, such that deleterious associations with memory were seen when both chemokines were elevated. These associations remained significant after adding APOE genotype and comparison (non‐chromosome 17) chemokines into the model. These chemokines predicted left medial temporal lobe volume and were not related to other cognitive domains. Discussion These results suggest a potentially selective role for MCP‐1 and eotaxin‐1 in memory dysfunction in the context of varied MCI and AD dementia phenotypes.

【 授权许可】

Unknown