Multifunctional and Self-Healable Intelligent Hydrogels for Cancer Drug Delivery and Promoting Tissue Regeneration In Vivo

Polymers

Fatemeh Khosravi¹  Erfan Rezvani Ghomi¹  Seeram Ramakrishna¹  Barbara Zavan²  Hongrong Luo³  Elham Pishavar⁴  Mahshid Naserifar⁴  Amelia Seifalian⁵ 

[1] Center for Nanotechnology and Sustainability, Department of Mechanical Engineering, National University of Singapore, Singapore 117581, Singapore;Department of Morphology, Experimental Medicine and Surgery, University of Ferrara, Via Fossato di Mortara 70, 44121 Ferrara, Italy;Engineering Research Center in Biomaterials, Sichuan University, Chengdu 610064, China;Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 91735, Iran;UCL Medical School, University College London, London WC1E 6BT, UK;

关键词: anti-cancer drug delivery;    regenerative medicine;    self-healing hydrogel;    cancer vaccination;   

DOI  :  10.3390/polym13162680

来源: DOAJ

【 摘 要 】

Regenerative medicine seeks to assess how materials fundamentally affect cellular functions to improve retaining, restoring, and revitalizing damaged tissues and cancer therapy. As potential candidates in regenerative medicine, hydrogels have attracted much attention due to mimicking of native cell-extracellular matrix (ECM) in cell biology, tissue engineering, and drug screening over the past two decades. In addition, hydrogels with a high capacity for drug loading and sustained release profile are applicable in drug delivery systems. Recently, self-healing supramolecular hydrogels, as a novel class of biomaterials, are being used in preclinical trials with benefits such as biocompatibility, native tissue mimicry, and injectability via a reversible crosslink. Meanwhile, the localized therapeutics agent delivery is beneficial due to the ability to deliver more doses of therapeutic agents to the targeted site and the ability to overcome post-surgical complications, inflammation, and infections. These highly potential materials can help address the limitations of current drug delivery systems and the high clinical demand for customized drug release systems. To this aim, the current review presents the state-of-the-art progress of multifunctional and self-healable hydrogels for a broad range of applications in cancer therapy, tissue engineering, and regenerative medicine.

【 授权许可】

Unknown