Convolutional Neural Network and Bidirectional Long Short-Term Memory-Based Method for Predicting Drug–Disease Associations

Cells

Chang Sun¹  Yilin Ye¹  Lianfeng Zhao¹  Ping Xuan¹  Tiangang Zhang² 

[1] School of Computer Science and Technology, Heilongjiang University, Harbin 150080, China;School of Mathematical Science, Heilongjiang University, Harbin 150080, China;

关键词: drug repositioning;    convolutional neural network;    drug research and development;    bidirectional long short-term memory;    attention mechanism at path level;   

DOI  :  10.3390/cells8070705

来源: DOAJ

【 摘 要 】

Identifying novel indications for approved drugs can accelerate drug development and reduce research costs. Most previous studies used shallow models for prioritizing the potential drug-related diseases and failed to deeply integrate the paths between drugs and diseases which may contain additional association information. A deep-learning-based method for predicting drug−disease associations by integrating useful information is needed. We proposed a novel method based on a convolutional neural network (CNN) and bidirectional long short-term memory (BiLSTM)—CBPred—for predicting drug-related diseases. Our method deeply integrates similarities and associations between drugs and diseases, and paths among drug-disease pairs. The CNN-based framework focuses on learning the original representation of a drug-disease pair from their similarities and associations. As the drug-disease association possibility also depends on the multiple paths between them, the BiLSTM-based framework mainly learns the path representation of the drug-disease pair. In addition, considering that different paths have discriminate contributions to the association prediction, an attention mechanism at path level is constructed. Our method, CBPred, showed better performance and retrieved more real associations in the front of the results, which is more important for biologists. Case studies further confirmed that CBPred can discover potential drug-disease associations.

【 授权许可】

Unknown