ZnT8 autoantibody prevalence is low in youth with type 2 diabetes and associated with higher insulin sensitivity, lower insulin secretion, and lower disposition index

Journal of Clinical & Translational Endocrinology

Silva Arslanian¹  Sherida Tollefsen²  Georgeanna Klingensmith³  Kimberly L. Drews⁴  Kenneth Copeland⁵  Terri H. Lipman⁶  Janine Higgins⁶  Philip Zeitler⁶  Robin Goland⁷ 

[1] Corresponding author at: The Biostatistics Center, George Washington University, 6110 Executive Boulevard Suite 750, Rockville, MD 20852, United States.;Children’s Hospital of Philadelphia, Philadelphia, PA, United States;Columbia University, New York, NY, United States;George Washington University Biostatistics Center, Rockville, United States;UPMC-Children’s Hospital of Pittsburgh, Pittsburgh, PA, United States;University of Colorado Anschutz Medical Campus, Aurora, CO, United States;University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States;

关键词: ZnT8;    Autoantibody;    Type 2 diabetes;    Child;    Adolescent;    Complications;   

DOI  :  

来源: DOAJ

【 摘 要 】

Aim: ZnT8 autoantibody positivity (ZnT8+) is associated with risk for type 1 diabetes and with metabolic complications in adults. Our aim was to assess prevalence of ZnT8 + in the Treatment of T2D in Adolescents and Youth (TODAY) cohort and describe associated phenotypic outcomes. Methods: TODAY participants were 13.98 ± 2.03 years with a confirmed diagnosis of T2D, BMI percentile of 97.69 ± 3.32 (64% female), and GAD- and IA2- at baseline. ZnT8 autoantibodies were measured at baseline and end of study. Results: 3 of 687 participants (0.29%) were ZnT8 + and there was one conversion (0.15%) from ZnT8- to ZnT8 + during the study. ZnT8A + individuals had higher HbA1c, HDL and LDL cholesterol, and IL-1β concentrations, and lower BMI, IL-6, and triglyceride concentrations compared to the TODAY cohort and ZnT8A- individuals. They also had higher insulin sensitivity with lower insulin secretion and disposition index, metabolically resembling T1D. All ZnT8 + participants experienced loss of glycemic control on randomized treatment, but exhibited lower rates of diabetic complications than other groups. Conclusion: Given the low rate of complications in ZnT8 + individuals, ZnT8 likely does not impact the clinical course of the disease in this population.

【 授权许可】

Unknown