The Infectious Bronchitis Coronavirus Pneumonia Model Presenting a Novel Insight for the SARS-CoV-2 Dissemination Route

Veterinary Sciences

Nina Bogdanchikova¹  Yanis Toledano-Magaña²  Yulia Kozlova³  Natalia Sigareva⁴  Alexey Pestryakov⁵  Tatyana Mironova⁶  Ekaterina Nefedova⁶  Vyacheslav Koptev⁶  Vasily Afonyushkin⁶  Anna S. Bobikova⁶  Nikolai Donchenko⁶  Viktoria Cherepushkina⁶  Natalia Davidova⁶  Nikolai Shkil⁶ 

[1] Centro de Nanociencias y Nanotecnología, Universidad Nacional Autónoma de México, Ensenada 22860, BC, Mexico;Escuela de Ciencias de la Salud Unidad Valle Dorado, Universidad Autónoma de Baja California, Ensenada 22890, BC, Mexico;Institute of Chemical Biology and Fundamental Medicine SB RAS, 630090 Novosibirsk, Russia;Molecular Biology Department, Federal State Budgetary Educational Institution Higher Education Novosibirsk State Agrarian University, 630090 Novosibirsk, Russia;Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia;Siberian Federal Scientific Center of Agro-BioTechnologies of Russian Academy of Sciences, Novosibirsk Region, Novosibirsk District, 630501 Krasnoobsk, Russia;

关键词: virucidal drugs;    IBV;    chickens;    Coronaviridae;    silver nanoparticles;    artificial ribonuclease;   

DOI  :  10.3390/vetsci8100239

来源: DOAJ

【 摘 要 】

Infectious bronchitis (IB) of chickens is a highly contagious disease characterized by damage of the respiratory system and reproductive organs in young animals caused by a virus of the genus Gamma coronavirus. The condition of the respiratory system caused by the IB virus in chickens has many similarities with the pathology of the respiratory system caused by SARS-CoV-2 in humans. The effectiveness of virucidal drugs (Argovit, Triviron, Ecocid, and lauric acid monoglyceride) was tested on chickens inoculated with a tenfold dose of a vaccine strain based on the attenuated virus H120 against IB of chickens. On the 6th day after inoculation, inflammatory changes in the intestines, lungs, and thymus were observed in the control group. The experimental groups were characterized by less pronounced inflammatory reactions and a lower proportion of thymus and lung probes containing genomic IB virus RNA. Since the virucidal activity of four orally administrated formulations was possible only in the intestine, the experimental data indirectly confirmed the hypothesis of the possibility of the predominant accumulation of coronaviruses in the intestine and subsequent lung damage due to the hematogenous redistribution of viral particles and IBV antigens. It was suggested that other coronaviruses including SARS-CoV-2 can implement a similar mechanism.

【 授权许可】

Unknown