Inverse Association Between Serum Vitamin B12 Concentration and Obesity Among Adults in the United States

Frontiers in Endocrinology

Minxian Sun¹  Linda G. Snetselaar²  Yang Du²  Buyun Liu²  Shuang Rong²  Yangbo Sun²  Guifeng Xu²  Wei Bao³ 

[1] Department of Endocrinology, Wuhan Central Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, United States;Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, IA, United States;Obesity Research and Education Initiative, University of Iowa, Iowa City, IA, United States;

关键词: vitamin B12;    nutrition;    micronutrient;    obesity;    adults;   

DOI  :  10.3389/fendo.2019.00414

来源: DOAJ

【 摘 要 】

Introduction: Several studies have suggested that vitamin B12 deficiency is more common in obese individuals. We evaluated the cross-sectional associations of serum vitamin B12 concentrations with obesity in a nationally representative sample of adults in the United States.Methods: We included 9,075 participants aged ≥20 years in the National Health and Nutrition Examination Survey 2011–2014. Serum vitamin B12 concentrations were measured by electrochemiluminescence immunoassay. Obesity was defined as BMI ≥30 kg/m2. We used logistic regression with sample weights to estimate the odds ratios (ORs) and 95% confidence intervals (CIs).Results: Serum vitamin B12 concentrations were lower among obese adults compared with non-obese adults. After adjustment for age, gender, race/ethnicity, socioeconomic status, dietary and lifestyle factors, use of medications that could affect the serum vitamin B12 levels, dietary supplement use and fasting time, the multivariable-adjusted ORs (95% CIs) of obesity were 1.00 (reference), 0.95 (0.79, 1.14), 0.86 (0.74, 0.99), and 0.71 (0.60, 0.84) (p for trend <0.001) for increasing quartiles of serum vitamin B12 concentrations.Conclusions: In a large nationally representative sample of U.S. adults, higher serum vitamin B12 levels were inversely associated with obesity. Further investigation is needed to understand the underlying mechanisms.

【 授权许可】

Unknown