Structure and Function of Caliciviral RNA Polymerases

Viruses

Ji-Hye Lee¹  Kyung Hyun Kim¹  Mi Sook Chung² 

[1] Department of Biotechnology and Bioinformatics, Korea University, Sejong 30019, Korea;Department of Food and Nutrition, Duksung Women’s University, Seoul 01369, Korea;

关键词: calicivirus;    polymerase;    structure;    interaction;    precursor;   

DOI  :  10.3390/v9110329

来源: DOAJ

【 摘 要 】

Caliciviruses are a leading agent of human and animal gastroenteritis and respiratory tract infections, which are growing concerns in immunocompromised individuals. However, no vaccines or therapeutics are yet available. Since the rapid rate of genetic evolution of caliciviruses is mainly due to the error-prone nature of RNA-dependent RNA polymerase (RdRp), this article focuses on recent studies of the structures and functions of RdRp from caliciviruses. It also provides recent advances in the interactions of RdRp with virion protein genome-linked (VPg) and RNA and the structural and functional features of its precursor.

【 授权许可】

Unknown