Green Synthesis of CeO2 Nanoparticles from the Abelmoschus esculentus Extract: Evaluation of Antioxidant, Anticancer, Antibacterial, and Wound-Healing Activities

Molecules

Atif Hanif¹  Amanullah Fatehmulla²  W. A. Farooq²  Muhammad Atif²  Nafeesah Yaqub²  Yasir Iqbal³  Muhammad Hammad Aziz³  Shafiq Ahmad⁴  Hafiz Ejaz Ahmed⁵  Zahida Batool⁵  Hijaz Ahmad⁶ 

[1] Botany and Microbiology Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia;Department of Physics and Astronomy, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;Department of Physics, COMSATS University Islamabad, Lahore 54000, Pakistan;Industrial Engineering Department, College of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia;Institute of Physics: The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan;Section of Mathematics, International Telematic University Uninettuno, Corso Vittorio Emanuele II, 39, 00186 Roma, Italy;

关键词: green synthesis;    nanobiotechnology;    antibacterial activity;    wound healing;    antioxidant;   

DOI  :  10.3390/molecules26154659

来源: DOAJ

【 摘 要 】

Metal oxide nanoparticles synthesized by the biological method represent the most recent research in nanotechnology. This study reports the rapid and ecofriendly approach for the synthesis of CeO₂ nanoparticles mediated using the Abelmoschus esculentus extract. The medicinal plant extract acts as both a reducing and stabilizing agent. The characterization of CeO₂ NPs was performed by scanning electron microscopy (SEM), X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV-Vis), and Fourier transform infrared spectroscopy (FTIR). The in vitro cytotoxicity of green synthesized CeO₂ was assessed against cervical cancerous cells (HeLa). The exposure of CeO₂ to HeLa cells at 10–125 µg/mL caused a loss in cellular viability against cervical cancerous cells in a dose-dependent manner. The antibacterial activity of the CeO₂ was assessed against S. aureus and K. pneumonia. A significant improvement in wound-healing progression was observed when cerium oxide nanoparticles were incorporated into the chitosan hydrogel membrane as a wound dressing.

【 授权许可】

Unknown