Association of genotypes of rs671 within ALDH2 with risk for gastric cardia adenocarcinoma in the Chinese Han population in high- and low-incidence areas

Cancer Biology & Medicine

Xin Song¹  Guo Yuan¹  Tao Jiang¹  Jia Huang¹  Tang-Juan Zhang¹  Xiao-Long Lv¹  Yao-Wen Zhang¹  Zong-Min Fan¹  Li-Dong Wang¹  Jian-Wei Ku¹  Shou-Jia Hu¹  Lu-Wen Wang¹  Xue-Ke Zhao²  Lian-Qun Zhang²  Fu-You Zhou²  Shuang Lv²  Teng Ma²  Min-Jie Wu²  Neng-Chao Wang²  Peng Zhang²  Guo-Qiang Kong²  Xin-Min Li²  Ling-Fen Ji²  Hui Meng² 

[1] ;Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China;

关键词: Gastric cardia adenocarcinoma;    rs671;    ALDH2;   

DOI  :  10.20892/j.issn.2095-3941.2016.0089

来源: DOAJ

【 摘 要 】

Objective : This study aimed to determine if gastric cardia adenocarcinoma (GCA) risk was associated with the lys (A or *2) allele at the rs671 (glu504lys) polymorphism within the aldehyde dehydrogenase 2 (ALDH2) gene in a Chinese Han population. We also aimed to investigate ALDH2 genotypic distributions between subjects from high- and low-incidence areas for both GCA and esophageal squamous cell carcinoma (ESCC).Methods : We designed a case-control study including 2,686 patients with GCA and 3,675 control subjects from high- and low-incidence areas for both GCA and ESCC in China. TaqMan allele discrimination assay was used to genotype the rs671 polymorphism. χ² test and binary logistic regression analysis were used to estimate the odds ratios for the development of GCA, and multivariate ordinal logistic regression was used to analyze ALDH2 genotypic distributions among different groups.Results : Compared with ALDH2*1/*1 homozygotes, ALDH2*1/*2 and ALDH2*2/*2 carriers did not increase the risk for GCA in the Chinese Han population (P>0.05). Interestingly, the ratio of homozygous or heterozygous ALDH2 *2 carriers in high-incidence areas for both GCA and ESCC was lower than that in low-incidence areas (P<0.001).Conclusions : Genotypes of rs671 at ALDH2 may not increase GCA susceptibility in Chinese Han populations. In addition, the ALDH2 genotypic distribution differs between Chinese Han populations from high- and low-incidence areas for both GCA and ESCC. Our findings may shed light on the possible genetic mechanism for the dramatic geographic differences of GCA occurrence in China.

【 授权许可】

Unknown