The Gilles de la Tourette Syndrome-Quality of Life Scale (GTS-QOL): A Validation in Japanese Patients

Frontiers in Psychiatry

Yu Hamamoto¹  Yosuke Eriguchi¹  Akane Suzuki¹  Yukiko Kano¹  Mayu Fujiwara²  Natsumi Matsuda³  Ryunosuke Goto⁴  Yukari Yokoyama⁵  Maiko Nonaka⁶ 

[1] Department of Child Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;Department of Child Psychiatry, The University of Tokyo Hospital, Tokyo, Japan;Department of Developmental Psychology, Faculty of Human Studies, Shirayuri University, Tokyo, Japan;Department of Pediatrics, The University of Tokyo Hospital, Tokyo, Japan;Department of Social Welfare, Faculty of Social Welfare, Nihon Fukushi University, Mihama, Japan;Graduate School of Education, The University of Tokyo, Tokyo, Japan;

关键词: Tourette Syndrome;    quality of life;    tics;    health-related quality of life;    Gilles de la Tourette Syndrome;    GTS-QOL—Gilles de la Tourette Syndrome–Quality of Life;   

DOI  :  10.3389/fpsyt.2021.797037

来源: DOAJ

【 摘 要 】

Background: Though Gilles de la Tourette's syndrome (GTS) has significant impact on the quality of life of its patients, measures of health-related quality of life (HR-QOL) specific to adolescents and adults with GTS were not developed until recently. The present study provides evidence on the validity of the Gilles de la Tourette Syndrome-Quality of Life Scale (GTS-QOL), the first disease-specific HR-QOL instrument for GTS patients, for the first time in an East Asian sample.Methods: One hundred and two Japanese individuals aged 13 and above with GTS were included in our study. Internal consistency was evaluated using Cronbach's alpha. The 4-factor structure of the GTS-QOL was assessed using confirmatory factor analysis, using goodness of fit indices, factor loadings of each questionnaire item, and covariances between factors. Validity was assessed using interscale correlations. Convergent and discriminate construct validity was evaluated using correlations with other scales such as the 28-item General Health Questionnaire, the Yale Global Tic Severity Scale, and the short version of the Padua Inventory.Results: Scaling assumptions were met. Internal consistency reliability was high, with a Cronbach's alpha of 0.96. Confirmatory factor analysis revealed sufficient factor loadings and goodness of fit. All measures of goodness of fit corroborated the fit of the 4-factor model. Standardized covariances between factors in the confirmatory factor analysis were >0.8. There were significant correlations with other well-validated scales, and thus convergent and discriminate construct validity was sufficient.Conclusion: The GTS-QOL is a valid and reliable instrument to measure disease-specific HR-QOL of GTS patients in Japan.

【 授权许可】

Unknown