Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges

Marine Drugs

Thierry Lacour¹  Philippe Amade²  Mohamed Mehiri²  Estelle Sfecci² 

[1] Biopreserv, 4 traverse Dupont, 06130 Grasse, France;Nice Institute of Chemistry, Marine Natural Product Team, University Nice Sophia Antipolis, Parc Valrose, 28 avenue de Valrose, 06108 Nice Cedex 02, France;

关键词: marine sponges;    Poecilosclerida;    alkaloids;    crambescidins;    batzelladines;    analytical tools;    bioactivity;   

DOI  :  10.3390/md14040077

来源: DOAJ

【 摘 要 】

Sessile marine sponges provide an abundance of unique and diversified scaffolds. In particular, marine guanidine alkaloids display a very wide range of biological applications. A large number of cyclic guanidine alkaloids, including crambines, crambescins, crambescidins, batzelladines or netamins have been isolated from Poecilosclerida marine sponges. In this review, we will explore the chemodiversity of tri- and pentacyclic guanidine alkaloids. NMR and MS data tools will also be provided, and an overview of the wide range of bioactivities of crambescidins and batzelladines derivatives will be given.

【 授权许可】

Unknown