Superparamagnetic Iron Oxide Nanoparticles Modified with Silica Layers as Potential Agents for Lung Cancer Treatment

Nanomaterials

Katarzyna Reczyńska¹  Kamil Kornaus¹  Elżbieta Pamuła¹  Witold Reczyński¹  Arkadiusz Zarzycki²  Marta Marszałek²  Wojciech Chrzanowski³ 

[1] Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Kraków, Poland;Institute of Nuclear Physics, Polish Academy of Sciences, ul. Radzikowskiego 152, 31-342 Kraków, Poland;Sydney Nano Institute, Faculty of Medicine and Health, Sydney School of Pharmacy, The University of Sydney, Pharmacy and Bank Building, Camperdown, NSW 2006, Australia;

关键词: lung cancer;    nanoparticles;    nanoformualtions;    controlled drug release;    drug delivery;    superparamagnetic iron oxide nanoparticles (SPIONs);   

DOI  :  10.3390/nano10061076

来源: DOAJ

【 摘 要 】

Superparamagnetic iron oxide nanoparticles (SPIONs) are promising drug delivery carriers and hyperthermia agents for the treatment of cancer. However, to ensure their safety in vivo, SPIONs must be modified in order to prevent unwanted iron release. Thus, SPIONs were coated with silica layers of different morphologies: non-porous (@SiO₂), mesoporous (@mSiO₂) or with a combination of non-porous and mesoporous layers (@SiO₂@mSiO₂) deposited via a sol–gel method. The presence of SiO₂ drastically changed the surface properties of the nanoparticles. The zeta potential changed from 19.6 ± 0.8 mV for SPIONs to −26.1 ± 0.1 mV for SPION@mSiO₂. The Brunauer–Emmett–Teller (BET) surface area increased from 7.54 ± 0.02 m²/g for SPIONs to 101.3 ± 2.8 m²/g for SPION@mSiO₂. All types of coatings significantly decreased iron release (at least 10 fold as compared to unmodified SPIONs). SPIONs and SPION@mSiO₂ were tested in vitro in contact with human lung epithelial cells (A549 and BEAS-2B). Both nanoparticle types were cytocompatible, although some delay in proliferation was observed for BEAS-2B cells as compared to A549 cells, which was correlated with increased cell velocity and nanoparticles uptake.

【 授权许可】

Unknown