Structural Characterization, Antimicrobial Activity and BSA/DNA Binding Affinity of New Silver(I) Complexes with Thianthrene and 1,8-Naphthyridine

Molecules

Franc Perdih¹  Iztok Turel¹  BiljanaĐ. Glišić²  TinaP. Andrejević²  DarkoP. Ašanin³  Sanja Skaro Bogojevic⁴  Jasmina Nikodinovic-Runic⁴  Dusan Milivojevic⁴  Ivana Aleksic⁴  MilošI. Djuran⁵ 

[1] Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia;Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovića 12, 34000 Kragujevac, Serbia;Department of Science, Institute for Information Technologies Kragujevac, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia;Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11042 Belgrade, Serbia;Serbian Academy of Sciences and Arts, Knez Mihailova 35, 11000 Belgrade, Serbia;

关键词: silver(I) complexes;    thianthrene;    1,8-naphthyridine;    antimicrobial activity;    Caenorhabditis elegans;    DNA/BSA interaction;   

DOI  :  10.3390/molecules26071871

来源: DOAJ

【 摘 要 】

Three new silver(I) complexes [Ag(NO₃)(tia)(H₂O)]_n (Ag1), [Ag(CF₃SO₃)(1,8-naph)]_n (Ag2) and [Ag₂(1,8-naph)₂(H₂O)_1.2](PF₆)₂ (Ag3), where tia is thianthrene and 1,8-naph is 1,8-naphthyridine, were synthesized and structurally characterized by different spectroscopic and electrochemical methods and their crystal structures were determined by single-crystal X-ray diffraction analysis. Their antimicrobial potential was evaluated against four bacterial and three Candida species, and the obtained results revealed that these complexes showed significant activity toward the Gram-positive Staphylococcus aureus, Gram-negative Pseudomonas aeruginosa and the investigated Candida species with minimal inhibitory concentration (MIC) values in the range 1.56–7.81 μg/mL. On the other hand, tia and 1,8-naph ligands were not active against the investigated strains, suggesting that their complexation with Ag(I) ion results in the formation of antimicrobial compounds. Moreover, low toxicity of the complexes was detected by in vivo model Caenorhabditis elegans. The interaction of the complexes with calf thymus DNA (ct-DNA) and bovine serum albumin (BSA) was studied to evaluate their binding affinity towards these biomolecules for possible insights into the mode of antimicrobial activity. The binding affinity of Ag1–3 to BSA was higher than that for DNA, indicating that proteins could be more favorable binding sites for these complexes in comparison to the nucleic acids.

【 授权许可】

Unknown