Proteotoxicity: A Fatal Consequence of Environmental Pollutants-Induced Impairments in Protein Clearance Machinery

Journal of Personalized Medicine

Surendra Kumar¹  RaviShankar Singh²  Vijay Kumar³  Jong-Joo Kim³  SandeepKumar Singh⁴  AshishKant Dubey⁵  AnandPrakash Singh⁶  Shweta Devi⁷ 

[1] Cytogenetics Lab, Department of Anatomy, All India Institute of Medical Sciences, New Delhi 110029, India;Department of Biochemistry, Microbiology & Immunology, University of Saskatchewan, Room 4D40, Health Sciences Building, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada;Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Korea;Department of Medical Genetics, SGPGIMS, Lucknow 226014, India;Department of Neurology, SGPGIMS, Lucknow 226014, India;Division of Cardiovascular Disease, The University of Alabama at Birmingham (UAB), 1720 2nd Ave South, Birmingham, AL 35294-1913, USA;Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research, Lucknow 226001, India;

关键词: protein misfolding;    molecular chaperones;    co-chaperone;    JUNQ;    IPOD;    INQ;   

DOI  :  10.3390/jpm11020069

来源: DOAJ

【 摘 要 】

A tightly regulated protein quality control (PQC) system maintains a healthy balance between correctly folded and misfolded protein species. This PQC system work with the help of a complex network comprised of molecular chaperones and proteostasis. Any intruder, especially environmental pollutants, disrupt the PQC network and lead to PQCs disruption, thus generating damaged and infectious protein. These misfolded/unfolded proteins are linked to several diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and cataracts. Numerous studies on proteins misfolding and disruption of PQCs by environmental pollutants highlight the necessity of detailed knowledge. This review represents the PQCs network and environmental pollutants’ impact on the PQC network, especially through the protein clearance system.

【 授权许可】

Unknown