Fighting Cancer with Bacteria and Their Toxins

International Journal of Molecular Sciences

Dragan Trivanović¹  Željka Peršurić²  Krešimir Pavelić³ 

[1] Department of Oncology and Haematology, General Hospital Pula, Santorijeva 24a, 52100 Pula, Croatia;Faculty of Chemical Engineering and Technology, University of Zagreb, Trg Marka Marulića 19, 10000 Zagreb, Croatia;Faculty of Medicine, Juraj Dobrila University of Pula, Zagrebačka 30, 52100 Pula, Croatia;

关键词: bacteria;    bacterial toxins;    lung cancer;    proteomics;    extracellular vesicles;   

DOI  :  10.3390/ijms222312980

来源: DOAJ

【 摘 要 】

Cancer is one of the most important global health problems that continues to demand new treatment strategies. Many bacteria that cause persistent infections play a role in carcinogenesis. However, since bacteria are well studied in terms of molecular mechanisms, they have been proposed as an interesting solution to treat cancer. In this review, we present the use of bacteria, and particularly bacterial toxins, in cancer therapy, highlighting the advantages and limitations of bacterial toxins. Proteomics, as one of the omics disciplines, is essential for the study of bacterial toxins. Advances in proteomics have contributed to better characterization of bacterial toxins, but also to the development of anticancer drugs based on bacterial toxins. In addition, we highlight the current state of knowledge in the rapidly developing field of bacterial extracellular vesicles, with a focus on their recent application as immunotherapeutic agents.

【 授权许可】

Unknown