Associations of NR5A2 Gene Polymorphisms with the Clinicopathological Characteristics and Survival ofGastric Cancer

International Journal of Molecular Sciences

Meilin Wang¹  Mulong Du¹  Zhengdong Zhang¹  Weida Gong²  Xunlei Zhang³  Cuiju Tang³  Lili Shen³  Meng Kuang³  Jinfei Chen³  Dongying Gu³  Xinying Huo³  Zhi Xu³  Chunxiang Cao³  Yongfei Tan⁴ 

[1] Department of Environmental Genomics, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, Nanjing 211166, China;Department of General Surgery, Yixing Tumor Hospital, Yixing 214200, China;Department of Oncology, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing 210006, China;Department of Surgery, Yixing People's Hospital, Yixing 214200, China;

关键词: NR5A2;    rs3790843;    rs3790844;    single nucleotide polymorphism;    gastric cancer;   

DOI  :  10.3390/ijms151222902

来源: DOAJ

【 摘 要 】

The orphan nuclear receptor (NR5A2), which belongs to the NR5A subfamily of nuclear receptors, is expressed in developing and adult tissues of endodermal origin, and can contribute to the development of several cancers through regulating cell proliferation. NR5A2 (rs3790843 and rs3790844) single nucleotide polymorphisms (SNPs) genotyping were examined in DNA samples, extracted from paraffin-embedded cancer tissue. Clinicopathologic and follow-up data were collected from 944 patients with gastric cancer (GC). Associations of the 2 SNPs with the progression and prognosis in gastric cancer patients wereanalyzed using the SPSS version 18.0. We found that NR5A2 rs3790843 polymorphism was significantly associated with the risk of GC which had regional lymph node metastasis(p = 0.044) or distant metastasis (p = 0.020). Our results also indicated that rs3790844 polymorphism was associated with the increased overall survival (OS) of GC patients in the dominant model (GG vs. GA/AA, HR (hazard ratio) = 0.823, 95% CI (confidence interval) = 0.679–0.997), suggesting a potential protective role of the variant A allele. Additionally, in the stratified analysis, both NR5A2 rs3790843 and rs3790844 polymorphism were associated with significantly lower risk of death in the groups of female, tumor size>5 cm in a dominant model. Our results represent the first demonstration that the NR5A2 rs3790844 polymorphism is associated with increased OS of GC patients in the dominant model, and similar results were found among the female group and tumor size >5 cm group for NR5A2 rs3790843 polymorphism. Further validation in other larger studies with different ethnic populations and functional evaluations are needed.

【 授权许可】

Unknown