A Comprehensive Descriptive Epidemiological and Clinical Analysis of SARS-CoV-2 in West-Mexico during COVID-19 Pandemic 2020

International Journal of Environmental Research and Public Health

José Sergio Zepeda-Nuño¹  Iris Monserrat Llamas-Covarrubias²  Enrique Santillán-López³  Ahtziri Socorro Carranza-Aranda³  Germán Muñoz-Sánchez³  Christian David Hernández-Silva³  J. Samael Rodríguez-Sanabria⁴  Moisés Ramos-Solano⁵  Mariel García-Chagollán⁶  Darbi Alfredo Zerpa-Hernandez⁶  José Francisco Muñoz-Valle⁶  Samuel García-Arellano⁶  Natali Vega-Magaña⁷  Guillermina Muñoz-Rios⁷  Gabriela Espinoza-De León⁷  Jesús Mora-Mora⁷  Oliver Viera-Segura⁷  Marcela Peña-Rodríguez⁷  Carlos Daniel Díaz-Palomera⁷ 

[1] Centro de Investigación y Diagnóstico de Patologia, Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico;Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, CP, Mexico;Doctorado en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico;Doctorado en Ciencias en Biología Molecular en Medicina, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico;INICIA, CUCS Universidad de Guadalajara, Guadalajara 44340, Mexico;Instituto de Investigación de Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico;Laboratorio de Diagnóstico de Enfermedades Emergentes y Reemergentes, Departamento de Microbiología y Patología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico;

关键词: SARS-CoV-2;    COVID-19;    epidemiology;    risk factors;    comorbidities;   

DOI  :  10.3390/ijerph182010644

来源: DOAJ

【 摘 要 】

This study aimed to summarize the epidemiological and clinical characteristics of COVID-19 from Western Mexico people during 2020. A retrospective analysis from an electronic database of people visiting a sentinel center for molecular SARS-CoV-2 confirmatory diagnosis by RT-PCR from April to December 2020 was carried out for epidemiological and clinical description of COVID-19. Out of 23,211 patients evaluated, 6918 (29.8%) were confirmed for SARS-CoV-2 infection (mean age 38.5 ± 13.99), mostly females (53.8%). Comorbidities, such as diabetes (34.7%), obesity (31.15%), and hypertension (31.8%), presented an increased odds OR = 1.27, CI = 1.14–1.41; OR = 1.08, CI = 1.01–1.16; and OR = 1.09, CI = 0.99–1.19, respectively, for viral-infection. Moreover, fever, headache, and dry cough were the most frequent symptoms. No infection difference among sex was found. Those patients >60 years old were prone to COVID-19 severity (OR = 3.59, CI = 2.10–6.14), evaluated by the number of manifested symptoms, increasing with age. In conclusion, a high SARS-CoV-2 prevalence was found in Western Mexico. Comorbidities were frequent in infected people; nevertheless, no association with disease outcomes was observed, in contrast with the highest disease severity risk found in older patients; however, continuous monitoring should be carried since comorbidities have been reported as aggravating factors. This study can help the health officials for the elaboration of planning efforts of the disease management and others in the future.

【 授权许可】

Unknown