Daily Exposure to Air Pollution Particulate Matter Is Associated with Atrial Fibrillation in High-Risk Patients

International Journal of Environmental Research and Public Health

Vittorio Calzolari¹  Rene Nangah Suh²  Franco Zoppo³  Diego Vaccari⁴  Barbara Ignatiuk⁵  Gianni Gasparini⁶  Gabriele Zanotto⁷  Giuseppe Allocca⁸  Elena Marras⁸  Emanuele Bertaglia⁹  Franco Folino⁹  Gianfranco Buja⁹  Sabino Iliceto⁹  Alessandro Benassi^1,10  Elisa Gallo^1,11  Rosanna Comoretto^1,11  Daniele Bottigliengo^1,11  Corrado Lanera^1,11  Dario Gregori^1,11 

[1]Department of Cardiology, Ca’ Foncello Hospital, 31100 Treviso, Italy

[2]Department of Cardiology, Civic Hospital, 30026 Portogruaro, Italy

[3]Department of Cardiology, Civic Hospital, 30035 Mirano, Italy

[4]Department of Cardiology, Civic Hospital, 31044 Montebelluna, Italy

[5]Department of Cardiology, Civic Hospital, 35043 Monselice, Italy

[6]Department of Cardiology, Dell’Angelo Hospital, 30174 Mestre, Italy

[7]Department of Cardiology, Mater Salutis Hospital, 37045 Legnago, Italy

[8]Department of Cardiology, S Maria dei Battuti Hospital, 31015 Conegliano, Italy

[9]Division of Cardiology, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy

[10]Regional Agency for Environmental Prevention and Protection of the Veneto Region, 35121 Padua, Italy

[11]Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35131 Padua, Italy

关键词: atrial fibrillation;    air pollution;    cardiovascular risk;   

DOI  :  10.3390/ijerph17176017

来源: DOAJ

【 摘 要 】

Several epidemiological studies found an association between acute exposure to fine particulate matter of less than 2.5 μm and 10 μm in aerodynamic diameter (PM_2.5 and PM₁₀) and cardiovascular diseases, ventricular fibrillation incidence and mortality. The effects of pollution on atrial fibrillation (AF) beyond the first several hours of exposure remain controversial. A total of 145 patients with implantable cardioverter-defibrillators (ICDs), cardiac resynchronization therapy defibrillators (ICD-CRT), or pacemakers were enrolled in this multicentric prospective study. Daily levels of PM_2.5 and PM₁₀ were collected from monitoring stations within 20 km of the patient’s residence. A Firth Logistic Regression model was used to evaluate the association between AF and daily exposure to PM_2.5 and PM₁₀. Exposure levels to PM_2.5 and PM₁₀ were moderate, being above the World Health Organization (WHO) PM_2.5 and PM₁₀ thresholds of 25 μg/m³ and 50 μg/m³, respectively, on 26% and 18% of the follow-up days. An association was found between daily levels of PM_2.5 and PM₁₀ and AF (95% confidence intervals (CIs) of 1.34–2.40 and 1.44–4.28, respectively) for an increase of 50 µg/m³ above the WHO threshold. Daily exposure to moderate PM_2.5 and PM₁₀ levels is associated with AF in patients who are not prone to AF.

【 授权许可】

Unknown