Recombinant Viruses for Cancer Therapy

Biomedicines

DariaS. Chulpanova¹  ValeriyaV. Solovyeva¹  KristinaV. Kitaeva¹  SvetlanaF. Khaiboullina¹  AlbertA. Rizvanov¹  StephenP. Dunham² 

[1] Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan 420008, Russia;School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Leicestershire LE12 5RD, UK;

关键词: recombinant viruses;    virus-based vaccines;    oncolytic viruses;    gene therapy;    cell therapy;    chimeric antigen receptor (CAR) T-cell therapy;   

DOI  :  10.3390/biomedicines6040094

来源: DOAJ

【 摘 要 】

Recombinant viruses are novel therapeutic agents that can be utilized for treatment of various diseases, including cancers. Recombinant viruses can be engineered to express foreign transgenes and have a broad tropism allowing gene expression in a wide range of host cells. They can be selected or designed for specific therapeutic goals; for example, recombinant viruses could be used to stimulate host immune response against tumor-specific antigens and therefore overcome the ability of the tumor to evade the host’s immune surveillance. Alternatively, recombinant viruses could express immunomodulatory genes which stimulate an anti-cancer immune response. Oncolytic viruses can replicate specifically in tumor cells and induce toxic effects leading to cell lysis and apoptosis. However, each of these approaches face certain difficulties that must be resolved to achieve maximum therapeutic efficacy. In this review we discuss actively developing approaches for cancer therapy based on recombinant viruses, problems that need to be overcome, and possible prospects for further development of recombinant virus based therapy.

【 授权许可】

Unknown