From Plasminogen to Plasmin: Role of Plasminogen Receptors in Human Cancer

International Journal of Molecular Sciences

Malgorzata Wygrecka¹  Lukasz Wujak¹  Dariusz Zakrzewicz¹  Miroslava Didiasova¹ 

[1] Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany;

关键词: actin;    annexin 2;    cytokeratin-8;    enolase-1;    plasmin;    plasminogen;    plasminogen receptor;   

DOI  :  10.3390/ijms151121229

来源: DOAJ

【 摘 要 】

Cell surface-associated proteolysis mediated by plasmin (PLA) is an essential feature of wound healing, angiogenesis and cell invasion, processes that are dysregulated in cancer development, progression and systemic spread. The generation of PLA, initiated by the binding of its precursor plasminogen (PLG) to the cell surface, is regulatedby an array of activators, inhibitors and receptors. In this review, we will highlightthe importance of the best-characterized components of the PLG/PLA cascade in the pathogenesis of cancer focusing on the role of the cell surface-PLG receptors (PLG-R). PLG-R overexpression has been associated with poor prognosis of cancer patients and resistance to chemotherapy. We will also discuss recent findings on the molecular mechanisms regulating cell surface expression and distribution of PLG-R.

【 授权许可】

Unknown