Identification of Major Psychiatric Disorders From Resting-State Electroencephalography Using a Machine Learning Approach

Frontiers in Psychiatry

Jung-Seok Choi¹  Jun-Young Lee¹  Chi-Hyun Choi²  Da Young Oh²  Su Mi Park²  Boram Jeong³  Donghwan Lee³  Hee Yeon Jung⁴ 

[1] Department of Psychiatry and Behavioral Science, Seoul National University College of Medicine, Seoul, South Korea;Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, South Korea;Department of Statistics, Ewha Womans University, Seoul, South Korea;Institute of Human Behavioral Medicine, Seoul National University Medical Research Center, Seoul, South Korea;

关键词: classification;    electroencephalography;    machine learning;    psychiatric disorder;    resting-state brain function;    power spectrum density;   

DOI  :  10.3389/fpsyt.2021.707581

来源: DOAJ

【 摘 要 】

We aimed to develop a machine learning (ML) classifier to detect and compare major psychiatric disorders using electroencephalography (EEG). We retrospectively collected data from medical records, intelligence quotient (IQ) scores from psychological assessments, and quantitative EEG (QEEG) at resting-state assessments from 945 subjects [850 patients with major psychiatric disorders (six large-categorical and nine specific disorders) and 95 healthy controls (HCs)]. A combination of QEEG parameters including power spectrum density (PSD) and functional connectivity (FC) at frequency bands was used to establish models for the binary classification between patients with each disorder and HCs. The support vector machine, random forest, and elastic net ML methods were applied, and prediction performances were compared. The elastic net model with IQ adjustment showed the highest accuracy. The best feature combinations and classification accuracies for discrimination between patients and HCs with adjusted IQ were as follows: schizophrenia = alpha PSD, 93.83%; trauma and stress-related disorders = beta FC, 91.21%; anxiety disorders = whole band PSD, 91.03%; mood disorders = theta FC, 89.26%; addictive disorders = theta PSD, 85.66%; and obsessive–compulsive disorder = gamma FC, 74.52%. Our findings suggest that ML in EEG may predict major psychiatric disorders and provide an objective index of psychiatric disorders.

【 授权许可】

Unknown