A Conscious Resting State fMRI Study in SLE Patients Without Major Neuropsychiatric Manifestations

Frontiers in Psychiatry

Yuqi Cheng¹  Xiufeng Xu¹  Zhongqi Xie²  Yueyin Zhao²  Zhaoping Lv²  Aiyun Lai²  Lin Xu³  Baoci Shan⁴  Chunrong Luo⁵  Hongjun Yu⁵  Shuang Liu⁶  Jian Xu⁶ 

[1] Department of Psychiatry, First Affiliated Hospital of Kunming Medical University, Kunming, China;Department of Rheumatology and Immunology, First Affiliated Hospital of Kunming Medical University, Kunming, China;Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China;Key Laboratory of Nuclear Analysis, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China;Magnetic Resonance Imaging Center, The First Hospital of Kunming, Kunming, China;Yunnan Key Laboratory of Laboratory Medicine, Kunming, China;

关键词: systemic lupus erythematosus patients without major neuropsychiatric manifestations (non-NPSLE patients);    resting-state functional magnetic resonance imaging (rs-fMRI);    regional homogeneity (ReHo);    disease activity;    anxiety;    depression;   

DOI  :  10.3389/fpsyt.2018.00677

来源: DOAJ

【 摘 要 】

Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the main causes of death in patients with systemic lupus erythematosus (SLE). Signs and symptoms of NPSLE are heterogeneous, and it is hard to diagnose, and treat NPSLE patients in the early stage. We conducted this study to explore the possible brain activity changes using resting state functional magnetic resonance imaging (rs-fMRI) in SLE patients without major neuropsychiatric manifestations (non-NPSLE patients). We also tried to investigate the possible associations among brain activity, disease activity, depression, and anxiety. In our study, 118 non-NPSLE patients and 81 healthy controls (HC) were recruited. Rs-fMRI data were used to calculate the regional homogeneity (ReHo) in all participants. We found decreased ReHo values in the fusiform gyrus and thalamus and increased ReHo values in the parahippocampal gyrus and uncus. The disease activity was positively correlated with ReHo values of the cerebellum and negatively correlated with values in the frontal gyrus. Several brain areas showed correlations with depressive and anxiety statuses. These results suggested that abnormal brain activities might occur before NPSLE and might be the foundation of anxiety and depression symptoms. Early detection and proper treatment of brain dysfunction might prevent the progression to NPSLE. More studies are needed to understand the complicated underlying mechanisms.

【 授权许可】

Unknown