Bovine α-lactalbumin hydrolysates (α-LAH) attenuate high-fat diet induced nonalcoholic fatty liver disease by modulating hepatic lipid metabolism in C57BL/6J mice

Journal of Functional Foods

Min Du¹  Jiajia Song²  Xueying Mao³  Jing Gao³ 

[1] College of Food Science and Nutritional Engineering, Key Laboratory of Functional Dairy, Ministry of Education, China Agricultural University, Beijing, China;Nutritional Engineering, China Agricultural University, Beijing, China;;Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science &

关键词: NAFLD;    Bovine α-lactalbumin hydrolysates;    High-fat diet;    PPARγ;    PPARα;   

DOI  :  

来源: DOAJ

【 摘 要 】

The effect of bovine α-lactalbumin hydrolysates (α-LAH) on attenuating high-fat diet (HFD) induced nonalcoholic fatty liver disease (NAFLD) was investigated. C57BL/6J mice were fed with HFD for 8 weeks to mimic the clinical features of NAFLD, and then were fed with HFD and bovine α-LAH at different doses (100, 200 and 400 mg/kg b.w.) for another 12 weeks to investigate the beneficial effects of bovine α-LAH on NAFLD. Our data showed that bovine α-LAH markedly reversed the increase of body weight gain, tissue weight, serum lipids, liver injury markers, and serum pro-inflammatory cytokines induced by HFD in C57BL/6J mice. Bovine α-LAH supplementation also ameliorated fat accumulation and oxidative stress, down-regulated PPARγ associated gene expression, and up-regulated PPARα associated gene expression in the liver of mice fed HFD. These findings suggested that bovine α-LAH is effective in attenuating HFD induced NAFLD in C57BL/6J mice.

【 授权许可】

Unknown