Integrating Chronic Obstructive Pulmonary Disease Treatment With 8-Week Tai Chi Chuan Practice: An Exploration of Mind-Body Intervention and Neural Mechanism

Frontiers in Human Neuroscience

Lan Zhang²  Tao Yang²  Qiang Tu²  Haoran Shen³  Gao-Xia Wei³  Li-Zhen Chen³  Guangxi Li⁴  Xiaoyan Yao⁴  Zhuoer Hu⁵ 

[1] CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China;Department of Neurology, Jingzhou No. 1 People’s Hospital and First Affiliated Hospital of Yangtze University, Jingzhou, China;Department of Psychology, University of Chinese Academy of Sciences, Beijing, China;Department of Pulmonary Medicine, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China;Sino-Danish Center for Education and Research, Beijing, China;Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China;

关键词: chronic obstructive pulmonary disease;    resting fMRI;    Tai Chi;    frontal lobe;    mind-body intervention;   

DOI  :  10.3389/fnhum.2022.849481

来源: DOAJ

【 摘 要 】

ObjectiveThis study aims to explore the effect of integrating routine treatment with Tai Chi Chuan (TCC) intervention on the clinical symptom of patients with Chronic Obstructive Pulmonary Disease (COPD) from clinical and neurological perspectives.MethodsTwenty patients with COPD were recruited for regular treatment combined with 8-week TCC rehabilitative practice. Clinical symptoms were evaluated by Chronic Obstructive Pulmonary Symptom Assessment Scale (CAT) and Modified Dyspnea Scale (mMRC) at baseline and after treatment. Resting-state MRI scan was also performed with multiline T2-weighted echo-planar imaging (EPI) to acquire their functional images before and after the treatment. TCC rehabilitation involved a total of 8 weeks of practice with 90 min per session, three times a week.ResultsAfter an 8-week integration routine treatment with TCC practice, the patient’s clinical symptoms improved significantly. Imaging analysis showed that COPD patients exhibited decreased Degree of Centrality (DC) in the right inferior frontal gyrus (IFG), right middle frontal gyrus, bilateral cingulate cortex, bilateral precuneus, and right precentral gyrus. Moreover, correlation analysis found that the decreased DC in the right IFG was positively correlated with the CAT improvements.ConclusionThe routine treatment involving TCC rehabilitation practice could improve the clinical symptoms of patients with COPD. The right IFG might be a key brain region to contribute to the neural mechanism underlying integrative intervention on the clinical symptoms in COPD. These findings provide neurological evidence for treating COPD rehabilitation practice with mind-body practice based on Chinese culture to some extent, which also advances the understanding of the efficacy of TCC as the adjuvant technology from a neuroscience perspective.Clinical Trial Registration:[http://www.chictr.org.cn/showproj.aspx?proj=45189], identifier [ChiCTR1900028335].

【 授权许可】

Unknown