Suzuki–Miyaura cross coupling is not an informative reaction to demonstrate the performance of new solvents

Beilstein Journal of Organic Chemistry

James Sherwood¹ 

[1] Green Chemistry Centre of Excellence, Department of Chemistry, University of York, Heslington, YO10 5DD, UK;

关键词: cross coupling;    green solvents;    palladium;    solvent selection;    suzuki reaction;   

DOI  :  10.3762/bjoc.16.89

来源: DOAJ

【 摘 要 】

The development and study of new solvents has become important due to a proliferation of regulations preventing or limiting the use of many conventional solvents. In this work, the suitability of the Suzuki–Miyaura reaction to demonstrate the usefulness of new solvents was evaluated, including Cyrene™, dimethyl isosorbide, ethyl lactate, 2-methyltetrahydrofuran (2-MeTHF), propylene carbonate, and γ-valerolactone (GVL). It was found that the cross coupling is often unaffected by the choice of solvent, and therefore the Suzuki–Miyaura reaction provides limited information regarding the usefulness of any particular solvent for organic synthesis.

【 授权许可】

Unknown