Long Term Therapy with Lenalidomide in a patient with POEMS Syndrome

European Journal of Case Reports in Internal Medicine

Arwa Shana'ah¹  Benjamin Chu²  Yvonne A Efebera²  Don M Benson²  Craig C Hofmeister² 

[1] Department of Pathology, Ohio State University;Division of Hematology, Department of Internal Medicine, Ohio State University;

关键词: lenalidomide, POEMS;   

DOI  :  10.12890/2014_000093

来源: DOAJ

【 摘 要 】

Lenalidomide is an effective therapy against malignant plasma cells and a potent agent against proinflammatory and proangiogenic cytokines. The use of lenalidomide in POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein with plasma cells, skin changes) has been reported, but its benefit in long-term use is not well established. A 55-year-old man with POEMS and debilitating polyneuropathy was treated with lenalidomide and dexamethasone followed by maintenance lenalidomide. He remains in haematologic remission and in complete recovery of functional status 3.5 years after diagnosis. This case supports the long-term use of lenalidomide in patients with POEMS syndrome.

【 授权许可】

Unknown