Tumefactive Brain Demyelination Accompanying MADSAM Neuropathy

Türk Nöroloji Dergisi

Çağrı Mesut Temuçin¹  Aslı Tuncer Kurne¹  Şefik Evren Erdener¹  Figen Söylemezoğlu²  Rahşan Göçmen³ 

[1] Hacettepe University Faculty Of Medicine, Department Of Neurology, Ankara, Turkey;Hacettepe University Faculty Of Medicine, Department Of Pathology, Ankara, Turkey;Hacettepe University Faculty Of Medicine, Department Of Radiology, Ankara, Turkey;

关键词: MADSAM;    neuropathy;    tumefactive;    brain;    demyelination;   

DOI  :  10.4274/tnd.68736

来源: DOAJ

【 摘 要 】

Multifocal acquired demyelinating sensory and motor (MADSAM) neuropathy is characterized by asymmetric multifocal motor and sensory loss and conduction blocks in peripheral nerves. Peripheral demyelinating diseases may be accompanied by demyelination in central nervous system (CNS). In this report, a MADSAM patient with a solitary tumefactive demyelinating lesion in brain is presented. Neuroimaging due to a visual field defect revealed a right parietooccipital lesion, which was initially misdiagnosed as a tumor. Pathological examination showed that it was demyelinating in nature. Peripheral nervous symptoms of the patient developed two years later and she was then diagnosed with MADSAM. There was prominent clinical and electrophysiological response to steroid treatment. Tumefactive brain involvement was not previously reported for MADSAM neuropathy, although it was documented in a single case with typical chronic inflammatory demyelinating polyneuropathy (CIDP). CNS involvement should therefore be considered in MADSAM patients.

【 授权许可】

Unknown