Old and New Biomarkers for Infection, Inflammation, and Autoimmunity in Treatment-Resistant Affective and Schizophrenic Spectrum Disorders

Pharmaceuticals

Karl Bechter¹  Christian Scheiber²  Julian M. Schneider²  Tanja Schulz²  E. Marion Schneider² 

[1] Clinic for Psychiatry and Psychotherapy II, Ulm University, 89312 Günzburg, Germany;Division of Experimental Anaesthesiology, Ulm University Hospital, 89081 Ulm, Germany;

关键词: affective disorders;    schizophrenia;    cerebrospinal fluid;    biomarkers;    immune phenotypes;    monocytes;   

DOI  :  10.3390/ph15030299

来源: DOAJ

【 摘 要 】

Affective (AF) and Schizophrenic (SZ) Spectrum disorders manifest with risk factors, involving inflammatory processes linked to infections and autoimmunity. This study searched for novel biomarkers in cerebrospinal fluid (CSF) and peripheral blood. A total of 29 AF and 39 SZ patients with treatment-resistant disease were included. In CSF, the chemokine IL-8 was significantly elevated in AF and SZ patients. IL-8 promotes chemotaxis by neutrophils and may originate from different tissues. S100B, a glia-derived brain damage marker, was higher in CSF from AF than SZ patients. Among the plasma-derived biomarkers, ferritin was elevated in AF and SZ. Soluble CD25, indicating T_reg dysfunction, was higher in SZ than in AF patients. Interferon-γ, implying virus-specific immune activation, was positive in selective AF patients, only. Both groups showed elevated expression of immunosuppressive CD33 on monocytes, but higher amounts of CD123⁺ plasmacytoid dendritic cells were restricted to SZ. In conclusion, chemotactic IL-8 indicates neuronal stress and inflammation in the CSF of both groups. Novel plasma-derived biomarkers such as sCD25 and monocytic CD33 distinguish SZ from AF with an autoimmune phenotype.

【 授权许可】

Unknown