Dementia as Risk Factor for Severe Coronavirus Disease 2019: A Case-Control Study

Frontiers in Aging Neuroscience

Angelo Iodice¹  Paolo Maggi¹  Filomena Simeone¹  Clarissa Camaioni²  Nicola Coppola²  Antonio Russo²  Mariantonietta Pisaturo²  Federica Calò²  Agnese Giaccone³  Biagio Pinchera³  Ivan Gentile³ 

[1] Infectious Disease Unit, AORN Caserta, Caserta, Italy;Infectious Diseases Unit, Department of Mental Health and Public Medicine, University of Campania Luigi Vanvitelli, Naples, Italy;Infectious Diseases Unit, Federico II University, Naples, Italy;

关键词: dementia;    SARS-CoV-2;    death;    severity;    COVID-19;   

DOI  :  10.3389/fnagi.2021.698184

来源: DOAJ

【 摘 要 】

BackgroundThe aim of the present study was to investigate the outcome of patients with SARS-CoV-2 infection and dementia.Patients and MethodsIn a multicenter, observational, 1:2 matched case-control study all 23 patients with a history of dementia, hospitalized with a diagnosis of SARS-CoV-2 infection from February 28th 2020 to January 31st 2021 were enrolled. For each Case, 2 patients without dementia observed in the same period study, pair matched for gender, age (±5 years), PaO2/FiO2 (P/F) ratio at admission (<200, or >200), number of comorbidities (±1; excluding dementia) were chosen (Control group).ResultsThe majority of patients were males (60.9% of Cases and Controls) and very elderly [median age 82 years (IQR: 75.5–85) in the Cases and 80 (IQR: 75.5–83.75) in the Controls]. The prevalence of co-pathologies was very high: all the Cases and 43 (93.5%) Controls showed a Charlson comorbidity index of at least 2. During hospitalization the patients in the Case group less frequently had a moderate disease of COVID-19 (35 vs. 67.4%, p = 0.02), more frequently a severe disease (48 vs. 22%, p = 0.03) and more frequently died (48 vs. 22%, p = 0.03). Moreover, during coronavirus disease 2019 (COVID-19), 14 (60.8%) patients in the Case group and 1 (2.1%; p < 0.000) in the Control group showed signs and symptoms of delirium.ConclusionPatients with dementia are vulnerable and have an increased risk of a severe disease and death when infected with COVID-19.

【 授权许可】

Unknown