The Effect of Magnetic Field Gradient and Gadolinium-Based MRI Contrast Agent Dotarem on Mouse Macrophages

Cells

Martha Suarez-Villagran¹  Jarek Wosik²  Ahmed Uosef³  Priyanka Chanana³  Rafik M. Ghobrial³  Malgorzata Kloc³  Nicole Vaughn³ 

[1]Physics Department, University of Houston, Houston, TX 77204, USA

[2]Texas Center for Superconductivity, University of Houston, Houston, TX 77204, USA

[3]The Houston Methodist Research Institute, Houston, TX 77030, USA

关键词: magnetic field gradient;    MRI;    gadolinium;    macrophage;    polarization;    mitochondria;   

DOI  :  10.3390/cells11050757

来源: DOAJ

【 摘 要 】

Magnetic resonance imaging (MRI) is widely used in diagnostic medicine. MRI uses the static magnetic field to polarize nuclei spins, fast-switching magnetic field gradients to generate temporal and spatial resolution, and radiofrequency (RF) electromagnetic waves to control the spin orientation. All these forms of magnetic static and electromagnetic RF fields interact with human tissue and cells. However, reports on the MRI technique’s effects on the cells and human body are often inconsistent or contradictory. In both research and clinical MRI, recent progress in improving sensitivity and resolution is associated with the increased magnetic field strength of MRI magnets. Additionally, to improve the contrast of the images, the MRI technique often employs contrast agents, such as gadolinium-based Dotarem, with effects on cells and organs that are still disputable and not fully understood. Application of higher magnetic fields requires revisiting previously observed or potentially possible bio-effects. This article focuses on the influence of a static magnetic field gradient with and without a gadolinium-based MRI contrast agent (Dotarem) and the cellular and molecular effects of Dotarem on macrophages.

【 授权许可】

Unknown