Extracellular Vesicles and Transforming Growth Factor β Signaling in Cancer

Frontiers in Cell and Developmental Biology

Dorival Mendes Rodrigues-Junior¹  Aristidis Moustakas¹  Carl-Henrik Heldin¹  Chrysoula Tsirigoti¹  Sai Kiang Lim² 

[1] Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden;Institute of Molecular and Cell Biology (A*-STAR), Singapore, Singapore;

关键词: cancer-associated fibroblast (CAF);    epithelial – mesenchymal transition (EMT);    extracellular vesicle (EV);    metastasis;    micro-RNA (miRNA);    transforming growth factor β (TGF-β);   

DOI  :  10.3389/fcell.2022.849938

来源: DOAJ

【 摘 要 】

Complexity in mechanisms that drive cancer development and progression is exemplified by the transforming growth factor β (TGF-β) signaling pathway, which suppresses early-stage hyperplasia, yet assists aggressive tumors to achieve metastasis. Of note, several molecules, including mRNAs, non-coding RNAs, and proteins known to be associated with the TGF-β pathway have been reported as constituents in the cargo of extracellular vesicles (EVs). EVs are secreted vesicles delimited by a lipid bilayer and play critical functions in intercellular communication, including regulation of the tumor microenvironment and cancer development. Thus, this review aims at summarizing the impact of EVs on TGF-β signaling by focusing on mechanisms by which EV cargo can influence tumorigenesis, metastatic spread, immune evasion and response to anti-cancer treatment. Moreover, we emphasize the potential of TGF-β-related molecules present in circulating EVs as useful biomarkers of prognosis, diagnosis, and prediction of response to treatment in cancer patients.

【 授权许可】

Unknown