Community-acquired bacteremia among HIV-infected and HIV-exposed uninfected children hospitalized with fever in Mozambique

International Journal of Infectious Diseases

Ernesto Zaqueu¹  Tebeb Gebretsadik²  Samuel Simbine³  Alice Manjate³  Fabião E. Maússe³  Darlenne B. Kenga³  Jahit Sacarlal³  Troy D. Moon⁴  Hermenegilda F. Fernando⁵  Pedro Charles⁶ 

[1] Central Hospital Quelimane, Quelimane, Mozambique;Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA;Department of Microbiology, Faculty of Medicine, University Eduardo Mondlane, Maputo, Mozambique;Department of Pediatrics, Division of Pediatric Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA;General Hospital Mavalane, Maputo, Mozambique;General Hospital Quelimane, Quelimane, Mozambique;

关键词: Bacteremia;    HIV;    pediatrics;    antibiotic sensitivity;    Mozambique;   

DOI  :  

来源: DOAJ

【 摘 要 】

ABSTRACT:Background: Bacteremia is a major cause of morbidity and mortality worldwide. Children infected with HIV present with patterns of bacteremia generally associated with poor prognosis. In Mozambique, data on bacteremia are sparce. Methods: We conducted an observational study of HIV-infected and HIV-exposed uninfected children, aged 0-59 months, hospitalized with fever between April 1, 2016 and February 28, 2019. A single bacterial culture was collected at admission. Descriptive statistics were used to summarize microorganisms detected and antibiotic susceptibility testing. Results: A total of 808 HIV-infected (90%) and HIV-exposed uninfected (10%) children were enrolled. Blood culture positivity was 12% (95% CI: 9.9%-14.4%). Five organisms accounted for most cases: Staphylococcus Aureus (37%), Klebsiella spp (11%), Salmonella spp (11%), Escherichia Coli (9%) and Micrococcus (7%). Antibiotic resistance was common. Nearly 70% of Staphylococcus Aureus were methicillin-resistant and roughly 50% of Klebsiella had ESBL production. Conclusion: Community-acquired bacteremia was common in HIV-infected and HIV-exposed uninfected children hospitalized in Mozambique with a febrile illness. High rates of MRSA and ESBL producing organisms has implications for empiric antibiotics utilized in Mozambique. Longitudinal data on the prevalence and antimicrobial resistance patterns of important pathogens are badly needed to guide policy for drug formulary expansion and antibiotic prescription guidelines.

【 授权许可】

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