Time Difference of Arrival on Contrast-Enhanced Ultrasound in Distinguishing Benign Inflammation From Malignant Peripheral Pulmonary Lesions

Frontiers in Oncology

Yanpeng Chu¹  Qianrong Xie¹  Jiasi Wang¹  Fanxin Zeng¹  Jianqiang Cai²  Hong Lin³  Xiaoxue Zheng⁴  Guoli Wei⁴  Fanwei Zeng⁴  Jianqiong Song⁴  Min Tang⁴  Yan Tang⁴  Xiaoyu Zhai⁵ 

[1] Department of Clinical Research Center, Dazhou Central Hospital, Dazhou, China;Department of Hepatobiliary Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;Department of Public Health Information, Sichuan Center for Disease Control and Prevention, Chengdu, China;Department of Ultrasound Imaging, Dazhou Central Hospital, Dazhou, China;Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Thoracic Medical Oncology, Peking University Cancer Hospital and Institute, Beijing, China;

关键词: contrast-enhanced ultrasound;    peripheral pulmonary lesions;    time difference of arrival;    benign inflammation lesions;    malignant lesions;   

DOI  :  10.3389/fonc.2020.578884

来源: DOAJ

【 摘 要 】

IntroductionWorldwide, the incidence and mortality of lung cancer are at the highest levels, and the most lesions are located in the lung periphery. Despite extensive screening and diagnosis, the pathologic types of peripheral pulmonary lesions (PPLs) are difficult to diagnose by noninvasive examination. This study aimed to identify a novel index—time difference of arrival (TDOA)—to discriminate between benign inflammation and malignant PPLs.MethodsUsing contrast-enhanced ultrasound (CEUS), we retrospectively analyzed 96 patients with PPLs who had undergone biopsy to confirm the pathologic types. All data were collected from Dazhou Central Hospital between December 2012 and July 2019. The parameters of CEUS were analyzed by two assistant chief physicians of ultrasound diagnosis. Area under the receiver operating characteristic curve analysis, sensitivity, specificity, positive predictive value, and negative predictive value were calculated to assess the diagnostic ability of different indices.ResultsWe found that the TDOA significantly distinguished benign inflammation from malignant lesions. The TDOA was markedly increased in patients with malignant lesions than benign inflammation lesions (P < 0.001). Compared with conventional time-intensity curve (TIC) indices, TDOA showed high diagnostic accuracy (area under the curve = 0.894). Moreover, conventional diagnostic indices did not affect the diagnostic performance of TDOA by adjusting the receiver operating characteristic curve.ConclusionTDOA is feasible for the diagnosis of benign inflammation and malignant PPLs.

【 授权许可】

Unknown