Chemo-Enzymatic Synthesis of Oligoglycerol Derivatives

Molecules

Sunil K. Sharma¹  Abhishek K. Singh¹  Rainer Haag²  Nicolas Galy³  Remi Nguyen³  Christophe Len³ 

[1] Department of Chemistry, University of Delhi, Delhi 110007, India;Institut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, Berlin 14195, Germany;Université de Technologie de Compiègne (UTC), CS 60319, Compiègne Cedex 60203, France;

关键词: glycerol oligomers;    Novozym 435;    chemo-enzymatic;    regioselectivity;    building blocks;   

DOI  :  10.3390/molecules21081038

来源: DOAJ

【 摘 要 】

A cleaner and greener method has been developed and used to synthesize 14 different functionalized oligomer derivatives of glycerol in moderate 29%–39% yields over three steps. After successive regioselective enzymatic acylation of the primary hydroxyl groups, etherification or esterification of the secondary hydroxyl groups and chemoselective enzymatic saponification, the target compounds can efficiently be used as versatile building blocks in organic and supramolecular chemistry.

【 授权许可】

Unknown